Pamela B. Meluh, Ph.D.
Research Associate

1980-1984 B.S. in Biology, Loyola College Maryland.

1984-1986 M.S. in Applied Molcular Biology, University of Maryland

1986-1992 Ph.D. in molecular Biology, Princeton University.

1992-1997 Post-doctoral Fellow, Carnegie Institute of Washington.

1993 Helen Hay Whitney Fellow.

1998-2004 Assistant Member, Memorial Sloan-Kettering Cancer Center.

2000 Pew Scholar in the Biomedical Sciences



Research Interests

SLAM (Synthetic Lethal Analysis by Microarray)

SUMO and ubiquitin pathways; centromere-kinetochore compex, histones. cell cycle, genome integrity, chromosome segregation, chromatin.


Stead K, Aguilar C, Hartman T, Drexel M, Meluh P, Guacci V. (2003). Pds5p regulates the maintenance of sister chromatid cohesion and is sumoylated to promote the dissolution of cohesion. J Cell Biol. 163(4):729-41.

Hsu JM, Huang J, Meluh PB, Laurent BC. (2003). The yeast RSC chromatin-remodeling complex is required for kinetochore function in chromosome segregation. Mol Cell Biol. 23(9):3202-15.

Best JL, Ganiatsas S, Agarwal S, Changou A, Salomoni P, Shirihai O, Meluh PB, Pandolfi PP, Zon LI. (2002). SUMO-1 protease-1 regulates gene transcription through PML. Mol Cell. 10(4):843-55.

Meluh PB, Strunnikov AV. (2002). Beyond the ABCs of CKC and SCC. Do centromeres orchestrate sister chromatid cohesion or vice versa? Eur J Biochem. 2002 May;269(9):2300-14. Review

Enquist-Newman M, Cheeseman IM, Van Goor D, Drubin DG, Meluh PB, Barnes G. (2001). Dad1p, third component of the Duo1p/Dam1p complex involved in kinetochore function and mitotic spindle integrity. Mol Biol Cell. 12(9):2601-13.

Meluh PB, Broach JR. (1999). Immunological analysis of yeast chromatin. Methods Enzymol. 304:414-30.

Meluh PB, Yang P, Glowczewski L, Koshland D, Smith MM. (1998). Cse4p is a component of the core centromere of Saccharomyces cerevisiae. Cell. 94(5):607-13

Meluh PB, Koshland D. (1997). Budding yeast centromere composition and assembly as revealed by in vivo cross-linking. Genes Dev. 11(24):3401-12.

Meluh PB, Koshland D. (1995). Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. Mol Biol Cell. 6(7):793-807.

O'Connell MJ, Meluh PB, Rose MD, Morris NR. (1993). Suppression of the bimC4 mitotic spindle defect by deletion of klpA, a gene encoding a KAR3-related kinesin-like protein in Aspergillus nidulans. J Cell Biol. 120(1):153-62.


portrait email

BRB 327
The Johns Hopkins University School of Medicine
733 N. Broadway / 335 Broadway Research Builfing
Baltimore, Maryland 21205