(Selected Publications 1995-2007)

For a full list of publication, please click here


Our laboratory is interested in the molecular mechanisms that modulate the communication between neurons in the brain. This modulation is critical for complex processes in the brain, including learning and memory and development. You can find out more about our work by clicking on "Research focus".

 


   
   
   Sia GM, Beique JC, Rumbaugh G, Cho R, Worley PF, Huganir RL. Interaction of the N-terminal domain of the AMPA receptor GluR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment. Neuron. 2007 Jul 5;55(1):87-102.
   
   Man HY, Sekine-Aizawa Y, Huganir RL. Regulation of {alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking through PKA phosphorylation of the Glu receptor 1 subunit. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3579-84.
   
   Beique JC, Lin DT, Kang MG, Aizawa H, Takamiya K, Huganir RL. Synapse-specific regulation of AMPA receptor function by PSD-95. Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19535-40.
 
   Boehm J, Kang MG, Johnson RC, Esteban J, Huganir RL, Malinow R. Synaptic incorporation of AMPA receptors during LTP is controlled by a PKC phosphorylation site on GluR1. Neuron. 2006 Jul 20;51(2):213-25.
 
   Steinberg JP, Takamiya K, Shen Y, Xia J, Rubio ME, Yu S, Jin W, Thomas GM, Linden DJ, Huganir RL. Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression. Neuron. 2006 Mar 16;49(6):845-60.
 
   Rumbaugh G, Adams JP, Kim JH, Huganir RL. SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4344-51.
 
   Thomas GM, Rumbaugh GR, Harrar DB, Huganir RL. Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission. Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15006-11.
 
   Hayashi T, Rumbaugh G, Huganir RL. Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites. Neuron. 2005 Sep 1;47(5):709-23.
 
      Kim CH, Takamiya K, Petralia RS, Sattler R, Yu S, Zhou W, Kalb R, Wenthold R, Huganir R. Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1. Nat Neurosci. 2005 Aug;8(8):985-7.
 
   Gardner SM, Takamiya K, Xia J, Suh JG, Johnson R, Yu S, Huganir RL. Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF. Neuron. 2005 Mar 24;45(6):903-15.
 
   Steinberg JP, Huganir RL, Linden DJ. N-ethylmaleimide-sensitive factor is required for the synaptic incorporation and removal of AMPA receptors during cerebellar long-term depression. Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18212-6.
 
   Sekine-Aizawa Y, Huganir RL. Imaging of receptor trafficking by using alpha-bungarotoxin-binding-site-tagged receptors. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17114-9.
 
   Thomas, G. M., and Huganir, R. L. (2004). MAPK cascade signalling and synaptic plasticity. Nat Rev Neurosci 5, 173-183.
 
  
 Takamiya, K., Kostourou, V., Adams, S., Jadeja, S., Chalepakis, G., Scambler, P. J., Huganir, R. L., and Adams, R. H. (2004). A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1. Nat Genet 36, 172-177.
 
     Chung, H. J., Steinberg, J. P., Huganir, R. L., and Linden, D. J. (2003). Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Science 300, 1751-1755.
 
     Lee, H. K., Takamiya, K., Han, J. S., Man, H., Kim, C. H., Rumbaugh, G., Yu, S., Ding, L., He, C., Petralia, R. S., et al. (2003). Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell 112, 631-643.
 
   Penzes, P., Beeser, A., Chernoff, J., Schiller, M. R., Eipper, B. A., Mains, R. E., and Huganir, R. L. (2003). Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron 37, 263-274.
 
     Song, I., and Huganir, R. L. (2002). Regulation of AMPA receptors during synaptic plasticity. Trends Neurosci 25, 578-588.
 
     Scannevin, R. H., and Huganir, R. L. (2000). Postsynaptic organization and regulation of excitatory synapses. Nat Rev Neurosci 1, 133-41.
 
   Xia, J., Chung, H. J., Wihler, C., Huganir, R. L., and Linden, D. J. (2000). Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins. Neuron 28, 499-510.
 
   Ye, B., Liao, D., Zhang, X., Zhang, P., Dong, H., and Huganir, R. L. (2000). GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex. Neuron 26, 603-17.
 
      Lee, H. K., Barbarosie, M., Kameyama, K., Bear, M. F., and Huganir, R. L. (2000). Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity. Nature 405, 955-9.
 
      Garner, C. C., Nash, J., and Huganir, R. L. (2000). PDZ domains in synapse assembly and signalling. Trends Cell Biol 10, 274-80.
 
   O'Brien, R.J., D. Xu, R.S. Petralia, O. Steward, R.L. Huganir, and P. Worley. 1999. Synaptic clustering of AMPA receptors by the extracellular immediate- early gene product Narp. Neuron. 23:309-23.
 
     Kim, J.H., and R.L. Huganir. 1999. Organization and regulation of proteins at synapses [published erratum appears in Curr Opin Cell Biol 1999 Jun;11(3):407-8]. Curr Opin Cell Biol. 11:248-54.
 
      Liao, D., X. Zhang, R. O'Brien, M.D. Ehlers, and R.L. Huganir. 1999. Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons. Nat Neurosci. 2:37-43.
 
   Xia, J., X. Zhang, J. Staudinger, and R.L. Huganir. 1999. Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1. Neuron. 22:179-87.
 
   Kameyama, K., H.K. Lee, M.F. Bear, and R.L. Huganir. 1998. Involvement of a postsynaptic protein kinase A substrate in the expression of homosynaptic long-term depression. Neuron. 21:1163-75.
 
   Lee, H.K., K. Kameyama, R.L. Huganir, and M.F. Bear. 1998. NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus. Neuron. 21:1151-62.
 
   O'Brien, R.J., S. Kamboj, M.D. Ehlers, K.R. Rosen, G.D. Fischbach, and R.L. Huganir. 1998. Activity-dependent modulation of synaptic AMPA receptor accumulation [see comments]. Neuron. 21:1067-78.
 
     Kamboj, S., and R.L. Huganir. 1998. Receptor clustering: activate to accumulate? Curr Biol. 8:R719-21.
 
   Zhang, S., M.D. Ehlers, J.P. Bernhardt, C.T. Su, and R.L. Huganir. 1998. Calmodulin mediates calcium-dependent inactivation of N-methyl-D- aspartate receptors. Neuron. 21:443-53.
 
   Song, I., S. Kamboj, J. Xia, H. Dong, D. Liao, and R.L. Huganir. 1998. Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors [see comments]. Neuron. 21:393-400.
 
     O'Brien, R.J., L.F. Lau, and R.L. Huganir. 1998. Molecular mechanisms of glutamate receptor clustering at excitatory synapses. Curr Opin Neurobiol. 8:364-9.
 
   Kim, J.H., D. Liao, L.F. Lau, and R.L. Huganir. 1998. SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. Neuron. 20:683-91.
 
     Brakeman, P.R., A.A. Lanahan, R. O'Brien, K. Roche, C.A. Barnes, R.L. Huganir, and P.F. Worley. 1997. Homer: a protein that selectively binds metabotropic glutamate receptors. Nature. 386:284-8.
 
     Dong, H., R.J. O'Brien, E.T. Fung, A.A. Lanahan, P.F. Worley, and R.L. Huganir. 1997. GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors. Nature. 386:279-84.
 
     Ehlers, M.D., A.L. Mammen, L.F. Lau, and R.L. Huganir. 1996. Synaptic targeting of glutamate receptors. Curr Opin Cell Biol. 8:484-9.
 
   Roche, K.W., R.J. O'Brien, A.L. Mammen, J. Bernhardt, and R.L. Huganir. 1996. Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit. Neuron. 16:1179-88.
 
   Gillespie, S.K., S. Balasubramanian, E.T. Fung, and R.L. Huganir. 1996. Rapsyn clusters and activates the synapse-specific receptor tyrosine kinase MuSK. Neuron. 16:953-62.
 
     Ehlers, M.D., S. Zhang, J.P. Bernhadt, and R.L. Huganir. 1996. Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit. Cell. 84:745-55.
 
     Ehlers, M.D., W.G. Tingley, and R.L. Huganir. 1995. Regulated subcellular distribution of the NR1 subunit of the NMDA receptor. Science. 269:1734-7.
 
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