Ochsner SA, Abraham D, Martin K, Ding W, McOwiti A, Kankanamge W, Wang Z, Andreano K, Hamilton RA, Chen Y, Hamilton A, Gantner ML, Dehart M, Qu S, Hilsenbeck SG, Becnel LB, Bridges D, Ma'ayan A, Huss JM, Stossi F, Foulds CE, Kralli A, McDonnell DP, McKenna NJ. (2019). The Signaling Pathways Project, an integrated 'omics knowledgebase for mammalian cellular signaling pathways. Sci Data. 6(1):252. Pubmed Cho Y, Tachibana S, Hazen BC, Moresco JJ, Yates JR 3rd, Kok B, Saez E, Ross RS, Russell AP, Kralli A. (2019). Perm1 regulates CaMKII activation and shapes skeletal muscle responses to endurance exercise training. Mol Metab. 23:88-97. Epub 2019 Feb 27. Pubmed Brown EL, Foletta VC, Wright CR, Sepulveda PV, Konstantopoulos N, Sanigorski A, Della Gatta P, Cameron-Smith D, Kralli A, Russell AP. (2018). PGC-1α and PGC-1β Increase Protein Synthesis via ERRα in C2C12 Myotubes. Front Physiol. 9:1336. eCollection 2018. Pubmed Brown EL, Hazen BC, Eury E, Wattez JS, Gantner ML, Albert V, Chau S, Sanchez-Alavez M, Conti B, Kralli A. (2018). Estrogen-Related Receptors Mediate the Adaptive Response of Brown Adipose Tissue to Adrenergic Stimulation. iScience. 2:221-237. Pubmed Jordan SD, Kriebs A, Vaughan M, Duglan D, Fan W, Henriksson E, Huber AL, Papp SJ, Nguyen M, Afetian M, Downes M, Yu RT, Kralli A, Evans RM, Lamia KA. (2017). Cell Metab. 26(1):243-255.e6. Pubmed Gantner ML, Hazen BC, Eury E, Brown EL, Kralli A. (2016). Complementary Roles of Estrogen-Related Receptors in Brown Adipocyte Thermogenic Function. Endocrinology. 157(12):4770-4781. Epub 2016 Oct 20. Pubmed Cho Y., Hazen B.C., Gandra P.G., Ward S.R., Schenk S., Russell A.P. and A. Kralli (2016). Perm1 enhances mitochondrial biogenesis, oxidative capacity and fatigue resistance in adult skeletal muscle. FASEB. pii: fj.15-276360. Pubmed Gantner M.L., Hazen B.C., Conkright J. and A. Kralli (2014). GADD45γ regulates the thermogenic capacity of brown adipose tissue. Proc. Natl. Acad. Sci. U S A. 111, 11870-11875. (Epub 2014 Jul 28). Pubmed Brown E.L., Snow R.J., Wright C.R., Cho Y., Wallace M.A., Kralli A. and A.P. Russell (2014). PGC-1α and PGC-1β increase CrT expression and creatine uptake in myotubes via ERRα. Biochim. Biophys. Acta 1843, 2937-2943. Pubmed Gan Z., Rumsey J., Hazen B.C., Lai L., Leone T.C., Vega R.B., Xie H., Conley K.E., Auwerx J., Smith S.R., Olson E.N., Kralli A. and D.P. Kelly. (2013). Nuclear Receptor-microRNA Circuitry Links Muscle Fiber Type to Energy Metabolism. J. Clin. Invest. 123, 2564-2575. Pubmed Foletta V.C., Brown E..L, Cho Y., Snow R.J., Kralli A. and A.P. Russell. (2013). Ndrg2 is a PGC-1α/ERRα target gene that controls protein synthesis and expression of contractile-type genes in C2C12 myotubes. Biochim Biophys Acta. 1833:3112-23. Pubmed Cho Y., Hazen B.C., Russell A.P. and A. Kralli. (2013). Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells. J Biol Chem. 288:25207-18. Pubmed Enguix N., Pardo R., González A., Simó R., Kralli A. and J. A. Villena. (2013). Mice lacking PGC-1β in adipose tissue reveal a dissociation between mitochondrial dysfunction and insulin resistance. Mol Metab. 2013 2:215-26. Pubmed Chambers K.T., Chen Z., Lai L., Leone T.C., Towle H.C., Kralli A., Crawford P.A. and B. N. Finck. (2013). PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner. Mol Metab. 2:194-204. Pubmed Russell A.P., Wada S., Vergani L., Hock M.B., Lamon S., Léger B., Ushida T., Cartoni R., Wadley G.D., Hespel P., Kralli A., Soraru G., Angelini C. and T. Akimoto. (2013). Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis. Neurobiol Dis. 49, 107-117. Pubmed Pardo R., Enguix N., Lasheras J., Feliu J.E., Kralli A. and J.A. Villena. (2011). Rosiglitazone-Induced Mitochondrial Biogenesis in White Adipose Tissue Is Independent of Peroxisome Proliferator-Activated Receptor γ Coactivator-1a. PLoS One 6, e26989. Pubmed Wallace M.A., Hock M.B., Hazen B.C., Kralli A., Snow R.J. and A.P. Russell. (2011). Striated muscle activator of Rho signalling (STARS) is a PGC-1α/oestrogen-related receptor-α target gene and is upregulated in human skeletal muscle after endurance exercise. J. Physiol. 589, 2027-2039. Pubmed Tiraby C., Hazen B.C., Gantner M.L. and A. Kralli. (2011). Estrogen-Related Receptor gamma promotes mesenchymal-to-epithelial transition and suppresses breast tumor growth. Cancer Res. 71, 2518-2528. Pubmed Chang J.S., Huypens P., Zhang Y., Black C., Kralli A., Gettys TW. (2010). Regulation of NT-PGC-1alpha subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1. J Biol Chem. 285(23):18039-50. Epub 2010 Mar 29. Pubmed Zhang Y., Huypens P., Adamson A.W., Chang J.S., Henagan T.M., Boudreau A., Lenard N.R., Burk D., Kleine J., Perwitz N., Shin J., Fasshauer M., Kralli A., Gettys T.W. (2009). Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1alpha. J Biol Chem. 284(47):32813-26. Epub 2009 Sep 22. Pubmed Hock M.B. and A. Kralli (2009). Transcriptional Control of Mitochondrial Biogenesis and Function. Annu. Rev. Physiol. 71, 177-203. Pubmed Hallberg M., Morganstein D.L., Kiskinis E., Shah K., Kralli A., Dilworth S.M., White R., Parker M.G. and M. Christian (2008). A functional interaction between RIP140 and PGC-1α regulates the expression of the lipid droplet protein CIDEA. Mol. Cell. Biol. 28, 6785-95. Pubmed Villena J.A. and A. Kralli (2008). ERRα: a metabolic function for the oldest orphan. Trends Endocrinol. Metab. 19, 269-76. Pubmed Olson B.L., Hock M.B., Ekholm-Reed S., Wohlschlegel J.A., Dev K.K., Kralli A1., and S.I. Reed1 (2008). SCFCdc4 Acts Antagonistically to the PGC-1α Transcriptional Coactivator by Targeting It for Ubiquitin-Mediated Proteolysis. Genes Dev. 22, 252-64. Pubmed Kressler D., Hock M.B., and A. Kralli (2007). Coactivators PGC-1β and SRC-1 Interact Functionally to Promote the Agonist Activity of the Selective Estrogen Receptor Modulator Tamoxifen. J. Biol. Chem. 281, 99-106. Pubmed Chen E.I., Hewel J., Krueger J.S., Tiraby C., Weber M.R., Kralli A., Becker K., Yates J.R. 3rd, and B. Felding-Habermann (2007). Adaptation of Energy Metabolism in Breast Cancer Brain Metastases. Cancer Res. 67, 1472-1486. Pubmed Sano, M., Izumi Y., Helenius K., Asakura M., Rossi D. J., Xie M., Taffet G., Hu L., Pautler R. G., Wilson C. R., Boudina S., Abel E. D., Taegtmeyer H., Scaglia F., Graham B. H., Kralli A., Shimizu N., Tanaka H., Makela T. P., and M.D. Schneider (2007). Menage-a-Trois 1 Is Critical for the Transcriptional Function of PPARgamma Coactivator 1. Cell Metab. 5, 129-142. Pubmed Villena J.A., Hock M.B., Chang W.Y., Barcas J.E., Giguère V., and A. Kralli (2007). Orphan nuclear receptor ERRα is essential for adaptive thermogenesis. Proc. Natl. Acad. Sci. USA 104, 1418-1423. Pubmed Thijssen-Timmer D.C., Platvoet-Ter Schiphorst M., Kwakkel J., Emter R., Kralli A., Wiersinga W.M., and O. Bakker (2006). PGC-1α regulates the isoform mRNA ratio of the alternatively spliced thyroid hormone receptor alpha transcript. J. Mol. Endocr. 37, 251-257. Pubmed Herzog B., Cardenas J., Hall R.K., Villena J.A., Budge P.J., Giguere V., Granner D.K., and A. Kralli (2006). Estrogen-related receptor α is a repressor of Phosphoenolpyruvate Carboxykinase gene transcription. J. Biol. Chem. 281, 99-106. Pubmed Teyssier C., Ma H., Emter R., Kralli A., and M.R. Stallcup (2005). Activation of Nuclear Receptor Coactivator PGC-1α by Arginine Methylation. Genes Dev. 19, 1466-73. Pubmed Cartoni R., Léger B., Hock M.B., Praz M., Crettenand A., Pich S., Ziltener J., Dériaz O., Zorzano A., Gobelet C., Kralli A., and A. P. Russell (2005). Mitofusins 1/2 and ERRα expression are increased in human skeletal muscle after physical exercise. Journal of Physiology 567, 349-58. Pubmed Schreiber S.N., Emter R., Hock M.B., Knutti D., Cardenas J., Podvinec M., Oakeley E.J. and A. Kralli (2004). The estrogen-related receptorα (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis. Proc. Natl. Acad. Sci. USA 101, 6472-6477. Pubmed Russell A.P., Feilchenfeldt J., Schreiber S., Praz M., Crettenand A., Gobelet C., Meier C.A., Bell D.R., Kralli A., Giacobino J.P., and O. Deriaz (2003). Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle. Diabetes. 52, 2874-2881. Pubmed Schreiber S.N., Knutti D., Brogli K., Uhlmann T. and A. Kralli (2003). The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha). J. Biol. Chem. 278, 9013-9018. Pubmed Emter R., Heese-Peck A. and A. Kralli (2002). ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms. FEBS Letters 521, 57-61. Pubmed Kressler, D., Schreiber, S., Knutti, D. and A. Kralli (2002). The PGC-1- related protein PERC is a selective coactivator of estrogen receptor alpha. J. Biol. Chem. 277, 13918-25. Pubmed Knutti D. and A. Kralli (2001). PGC-1, a versatile coactivator. Trends in Endocrinology & Metabolism 12, 360-365. Pubmed Knutti D., Kressler D. and A. Kralli (2001). Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor. Proc. Natl. Acad. Sci. USA 98, 9713-9718. Pubmed Sitcheran R., Emter R., Kralli A. and K.R. Yamamoto (2000). A genetic analysis of glucocorticoid receptor signaling: identification and characterization of Ligand-Effect Modulators in S. cerevisiae. Genetics 156, 963-972. Pubmed Knutti D., Kaul A. and A. Kralli (2000). A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. Mol. Cell. Biol. 20, 2411-2422. Pubmed Mäser P., Sütterlin C., Kralli A. and R. Kaminsky (1999). A nucleoside transporter from Trypanosoma brucei involved in drug resistance.Science 285, 242-244. Pubmed Garabedian M.J., Iniguez-Lluhi J.A. and A. Kralli (1999). Yeast as a system for the study of nuclear receptor function. In "Steroid/Nuclear Receptor Superfamily: Practical Approach" edit. D. Picard, Oxford University Press, 233-259. Egner R., Rosenthal F.E., Kralli A., Sanglard D. and K. Kuchler (1998). Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP binding cassette multidrug resistance transporter. Mol. Biol. Cell 9, 523-543. Pubmed Kralli A. and K.R. Yamamoto (1996). An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones. J. Biol. Chem. 271, 17152-17156. Pubmed Bohen S.P., Kralli A. and K.R. Yamamoto (1995). Hold 'em and Fold 'em: Chaperones and Signal Transduction. Science 268, 1303-1304. Pubmed Kralli A., Bohen S.P. and K.R. Yamamoto (1995). LEM1, an ATP-Binding Cassette transporter, selectively modulates the biological potency of steroid hormones. Proc. Natl. Acad. Sci. USA 92, 4701-4705. Pubmed Ye X., Kralli A., Ge R., Ricciardi R.P. and B.B. Knowles (1994). Down-regulation of MHC class I antigen in insulinoma cells controlled by the R1 element of the H-2 enhancer. Oncogene 9, 1195-204. Pubmed Kralli A., Ge R., Graeven U., Ricciardi R.P. and R. Weinmann (1992). Negative regulation of the major histocompatibility complex class I enhancer in adenovirus type 12-transformed cells via a retinoic acid response element. Journal of Virology 66, 6979-88. Pubmed Ge R., Kralli A., Weinmann R. and R.P. Ricciardi (1992). Down-regulation of the major histocompatibility complex class I enhancer in adenovirus type 12-transformed cells is accompanied by an increase in factor binding. Journal of Virology 66, 6969-78. Pubmed Horikoshi N., Maguire K., Kralli A., Maldonado E., Reinberg D. and R. Weinmann (1991). Direct interaction between adenovirus E1A protein and the TATA box binding transcription factor IID. Proc. Natl. Acad. Sci. USA 88, 5124-5128. Pubmed