Enzymatic Capture of an Extrahelical Thymine in the Search for Uracil in DNA. Nature 449, 433-438.
Timing facilitated site transfer of an enzyme on DNA. Nature Chem Biol 8, 205–210
Detection of damaged DNA bases by DNA glycosylase enzymes. Biochemistry 49, 4957-4967
Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration. PNAS 110, 448-457
Impact of linker strain and flexibility in the design of a fragment-based inhibitor. Nature Chem Biol 5, 407-413.
Local sequence targeting in the AID:APOBEC family differentially impacts retroviral restriction and antibody
diversification. J Biol Chem 285 40956-64
Indirect Detection of Labile Solute Proton Spectra via the Water Signal Using Frequency-Labeled Exchange (FLEX) Transfer. JACS 132, 1813-1815.

Welcome to the Stivers Lab Webpage

Our laboratory focuses on the general problem of specific molecular recognition in biological systems. One major area of focus is the role of dNTP pool levels in cancer therapy and innate immunity against viruses. We are also interested in fundamental problems in DNA damage recognition and repair and the design of small molecule inhibitors against DNA repair enzyme targets. We use a wide breadth of molecular, genetic and biophysical approaches that together shed light on aspects of molecular recognition that are not apparent from structural studies alone. Our long-range goal is to use this understanding to identify new drug targets, and design novel small molecules that could become starting points for new chemotherapy or antiviral drugs.