Our laboratory focuses on the general problem of specific molecular recognition in biological systems. One major area of focus is the role of dNTP pool levels in cancer therapy and innate immunity against viruses. We are also interested in fundamental problems in DNA damage recognition and repair and the design of small molecule inhibitors against DNA repair enzyme targets. We use a wide breadth of molecular, genetic and biophysical approaches that together shed light on aspects of molecular recognition that are not apparent from structural studies alone. Our long-range goal is to use this understanding to identify new drug targets, and design novel small molecules that could become starting points for new chemotherapy or antiviral drugs.