Other WIF-B Experts                                                         

 Doris Cassio
 Equipe Prisme
 Unite INSERM 442
 Signalisation et Calcium
 Batiment 443 Universite Paris-Sud
 91405 ORSAY Cedex
 Phone: 01 69 15 68 58

 Fax: 01 69 15 58 93
 Email: doris.cassio@ibaic.u-psud.fr

 Gudrun Ihrke

 The Welcome Trust Center for 
 Molecular Mechanisms in Disease
 University of Cambridge
 Department of Clinical Biochemistry
 Welcome Trust/MRC Building, Hills Road
 Cambridge CB2 2XY , UK

 Phone: (+44 1223) 336782

 Fax: (+44 1223) 762630
 Email: gi200@cus.cam.ac.uk

 Pam Tuma

 Assistant Professor

  Biology Department
 The Catholic University Of America
 620 Michigan Avenue, NE
 McCort-Ward Building , Room 103
 Washington, DC 20064
 Phone: 202-319-6681
 Email: tuma@cua.edu


   WIF-B Journal References
Alvarez, C., Fujita, H., Hubbard, A., and Sztul, E. (1999). ER to Golgi transport: Requirement for p115 at a pre-Golgi VTC stage. J Cell Biol 147, 1205-22.

Bender, V., Bravo, P., Decaens, C., and Cassio, D. (1999). The structural and functional polarity of the hepatic human/rat hybrid WIF-B is a stable and dominant trait. Hepatology 30, 1002-10.

Bravo, P., Bender, V., and Cassio, D. (1998). Efficient in vitro vectorial transport of a fluorescent conjugated bile acid analogue by polarized hepatic hybrid WIF-B and WIF-B9 cells. Hepatology 27, 576-83.

Cassio, D., Hamon-Benais, C., Guerin, M., and Lecoq, O. (1991). Hybrid Cell Lines Constitute a Potential Reservoir of Polarized Cells: Isolation and Study of Highly Differentiated Hepatoma-derived Hybrid Cells Able to Form Functional Bile Canaliculi In V itro. The Journal of Cell Biology 115, 1397-1408.

Chaumontet, C., Mazzoleni, G., Decaens, C., Bex, V., Cassio, D., and Martel, P. (1998). The polarized hepatic human/rat hybrid WIF 12-1 and WIF-B cells communicate efficiently in vitro via connexin 32-constituted gap junctions. Hepatology 28, 164-72.

Decaens, C., Rodriguez, P., Bouchaud, C., and Cassio, D. (1996). Establishment of hepatic cell polarity in the rat hepatoma-human fibroblast hybrid WIF-B9. A biphasic phenomenon going from a simple epithelial polarized phenotype to an hepatic polarized one. J Cell Sci 109, 1623-35.

Guillonneau, F., Drechou, A., Pous, C., Chevalier, S., Lardeux, B., Cassio, D., and Durand, G. (1999). Hepatocyte differentiation of WIF-B cells includes a high capacity of interleukin-6-mediated induction of alpha 1-acid glycoprotein and alpha 2-macroglobulin. Biochim Biophys Acta 1448, 403-8.

Hayes, J. H., Soroka, C. J., Rios-Velez, L., and Boyer, J. L. (1999). Hepatic sequestration and modulation of the canalicular transport of the organic cation, daunorubicin, in the Rat. Hepatology 29, 483-93.

Ihrke, G., Neufeld, E. B., Meads, T., Shanks, M. R., Cassio, D., Laurent, M., Schroer, T. A., Pagano, R. E., and Hubbard, A. L. (1993). WIF-B cells: an in vitro model for studies of hepatocyte polarity. J Cell Biol 123, 1761-75.

Ihrke, G., Martin, G. V., Shanks, M. R., Schrader, M., Schroer, T. A., and Hubbard, A. L. (1998). Apical plasma membrane proteins and endolyn-78 travel through a subapical compartment in polarized WIF-B hepatocytes. J Cell Biol 141, 115-33.

Ihrke, G., Gray, S. R., and Luzio, J. P. (J 2000 Jan 15). Endolyn is a mucin-like type I membrane protein targeted to lysosomes by its cytoplasmic tail. Biochem 345 Pt 2, 287-96.

Konieczko, E. M., Ralston, A. K., Crawford, A. R., Karpen, S. J., and Crawford, J. M. (1998). Enhanced Na+-dependent bile salt uptake by WIF-B cells, a rat hepatoma hybrid cell line, following growth in the presence of a physiological bile salt. Hepatology 27, 191-9.

Meads, T., and Schroer, T. A. (1995). Polarity and nucleation of microtubules in polarized epithelial cells. Cell Motil Cytoskeleton 32, 273-88.

Nies, A. T., Cantz, T., Brom, M., Leier, I., and Keppler, D. (1998). Expression of the apical conjugate export pump, Mrp2, in the polarized hepatoma cell line, WIF-B. Hepatology 28, 1332-40.

Pons, M., Ihrke, G., Koch, S., Biermer, M., Pol, A., Grewal, T., Jackle, S., and Enrich, C. (Cell Res 2000 May 25). Late endocytic compartments are major sites of annexin VI localization in NRK fibroblasts and polarized WIF-B hepatoma cells [In Process Citation]. Exp 257, 33-47.

Pous, C., Chabin, K., Drechou, A., Barbot, L., Phung-Koskas, T., Settegrana, C., Bourguet-Kondracki, M. L., Maurice, M., Cassio, D., Guyot, M., and Durand, G. (1998). Functional specialization of stable and dynamic microtubules in protein traffic in WIF-B cells. J Cell Biol 142, 153-65.

Sai, Y., Nies, A. T., and Arias, I. M. (1999). Bile acid secretion and direct targeting of mdr1-green fluorescent protein from Golgi to the canalicular membrane in polarized WIF-B cells. J Cell Sci 112, 4535-45.

Sellem, C., Cassio, D., and Weiss, M. C. (1981). No extinction of tyrosine aminotransferase inducibility in rat hepatoma-human fibroblast hybrids containing the human X chromosome. Cytogenetics and Cell Genetics 30, 47-49.

Shanks, M. R., Cassio, D., Lecoq, O., and Hubbard, A. L. (1994). An improved polarized rat hepatoma hybrid cell line. Generation and comparison with its hepatoma relatives and hepatocytes in vivo. J Cell Sci 107, 813-25.

Sturm, E., Zimmerman, T. L., Crawford, A. R., Svetlov, S. I., Sundaram, P., Ferrara, J. L., Karpen, S. J., and Crawford, J. M. (2000 Jan). Endotoxin-stimulated macrophages decrease bile acid uptake in WIF-B cells, a rat hepatoma hybrid cell line. Hepatology 31, 124-30.

Tuma, P. L., Finnegan, C. M., Yi, J. H., and Hubbard, A. L. (1999). Evidence for apical endocytosis in polarized hepatic cells: phosphoinositide 3-kinase inhibitors lead to the lysosomal accumulation of resident apical plasma membrane proteins. J Cell Biol 145, 1089-102.