The Goley Lab is part of the Department of Biological Chemistry at the Johns Hopkins University School of Medicine in Baltimore, MD. We are a bacterial cell biology lab broadly interested in understanding how bacterial cells grow and divide with regularity and accuracy. We use cell biological, biochemical, genetic, and structural approaches to dissect cellular processes with the aim of understanding how they work in molecular detail. A detailed understanding of the fundamental mechanisms of bacterial growth is required to confront the growing crisis in antibacterial resistance. We get really excited about our research.

Johns Hopkins University School of Medicine
Latest News
Aug 2019: Wanda Figueroa-Cuilan joined us as the lab’s first postdoc! Welcome to Hopkins and Baltimore, Wanda!
June 2019:
Both Selam and PJ graduated and moved on to postdoctoral positions. We’ll miss you both!!
May 2019: Kousik and Jordan’s work defining determinants of FtsZ CTL-dependent regulation of PG metabolism was pre-printed on bioRxiv. Let us know what you think!
May 2019:
BCMB student Erika Smith joins the lab for her thesis work! Welcome, Erika!
Mar 2019:
PJ’s paper on FzlA’s role in activation of cell wall synthesis for cell division was accepted in Current Biology! Congrats to PJ and all of our awesome collaborators!
Mar 2019:
BCMB first year students Erika Smith and Alyshia Scholl joined us for the third rotation. Welcome Alyshia and Erika!
Feb 2019:
Selam was recognized with the Michael Shanoff Award for Hopkins Medicine Young Investigator’s Day 2019! Way to go Selam!!
Feb 2019:
Selam’s latest pre-print on the role of the transcriptional regulator CdnL in supporting metabolic homeostasis and morphogenesis is posted on bioRxiv. Please send us your feedback!
n 2019: BCMB first year Chad Hicks joined us for his second rotation. Welcome, Chad!
Oct 2018: PJ’s latest work on FzlA-dependent activation of FtsWI-mediated PG synthesis for division is now on bioRxiv!

Selected Recent Publications
An essential regulator of bacterial division links FtsZ to cell wall synthase activation (2019) Curr Biol
FtsZ assembles into species- and disordered linker-dependent superstructures on membranes in vitro.
Sundararajan et al (2018) Mol Micro

The disordered linker of FtsZ regulates its assembly dynamics and superstructure.
Sundararajan (2017) JBC

An FtsZ-binding protein regulates the rate of constriction during Caulobacter cell division.
Lariviere et al (2018) Mol Micro