The Goley Lab is part of the Department of Biological Chemistry at the Johns Hopkins University School of Medicine in Baltimore, MD. We are a bacterial cell biology lab broadly interested in understanding how bacterial cells grow and divide with regularity and accuracy. We use cell biological, biochemical, genetic, and structural approaches to dissect cellular processes with the aim of understanding how they work in molecular detail. A detailed understanding of the fundamental mechanisms of bacterial growth is required to confront the growing crisis in antibacterial resistance. We get really excited about our research.
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Johns Hopkins University School of Medicine
Latest News
Mar 2019: BCMB first year students Erika Smith and Alyshia Scholl joined us for the third rotation. Welcome Alyshia and Erika!
Feb 2019:
Selam was recognized with the Michael Shanoff Award for Hopkins Medicine Young Investigator’s Day 2019! Way to go Selam!!
Feb 2019:
Selam’s latest pre-print on the role of the transcriptional regulator CdnL in supporting metabolic homeostasis and morphogenesis is posted on bioRxiv. Please send us your feedback!
Ja
n 2019: BCMB first year Chad Hicks joined us for his second rotation. Welcome, Chad!
Oct 2018: PJ’s latest work on FzlA-dependent activation of FtsWI-mediated PG synthesis for division is now on bioRxiv!
Sept 2018:
BCMB student Marie Stoltzfus joined us for her first rotation. Welcome, Marie!
Sept 2018: Our collaboration with Pam Brown’s lab on Agrobacterium FtsZs is out as a pre-print on bioRxiv.

Selected Recent Publications
SLBGraphAbs
FtsZ assembles into species- and disordered linker-dependent superstructures on membranes in vitro.
Sundararajan et al (2018) Mol Micro

FzlAGraphAbs
An FtsZ-binding protein regulates the rate of constriction during Caulobacter cell division.
Lariviere et al (2018) Mol Micro


FtsEmodel
FtsEX links FtsZ to cell wall hydrolysis pathways to promote late stages of cell division.
Meier et al (2017) PLoS Genetics

CTLpolym
The disordered linker of FtsZ regulates its assembly dynamics and superstructure.
Sundararajan (2017) JBC

Funding
NIGMSLogoS JHULogoS JHUSOMLogoS2