Seydoux Lab home page

Geraldine Seydoux
Professor
Molecular Biology and Genetics
Center for Cell Dynamics
Howard Hughes Medical Institute
Johns Hopkins University School of Medicine
 
725 N. Wolfe Street
706 PCTB
Baltimore, MD 21205
 
Office: 410-614-4622
Fax: 410-502-6718

Polarity

Hao, Y., Boyd, L., Seydoux, G. (2006). Stabilization of cell polarity by the RING protein PAR-2. Developmental Cell 10, 199­208. [PDF reprint] [Supplemental Material]

Seydoux, G. (2004) Surfing the actomyosin wave: polarization of the C. elegans zygote. Developmental Cell 7, 285-286. [PDF reprint]

Pellettieri, J., Reinke, V. , Kim, S. K. and Seydoux, G. (2003) Coordinate activation of maternal protein degradation during the Egg-to-Embryo Transition in C. elegans. Developmental Cell 5, 451–462. [PDF reprint]

Cuenca, A., Schetter A. , Aceto D., Kemphues K., Seydoux, G. (2003). Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases. Development 130, 1255-1265. [PDF reprint]

Pellettieri and Seydoux (2002). Anterior/Posterior Polarity in Worms and Flies – PARallels and Differences. Science, 298:1946-50. [PDF reprint]

Wallenfang, M. R., and Seydoux, G. (2000). Polarization of the anterior-posterior axis of C. elegans is a microtubule-directed process. Nature 408, 89-92. [PDF reprint]

Germline

Stitzel, M. and Seydoux, G (2007). Regulation of the oocyte-to-zygote transition. Science, 316(5823):407-8. [Abstract] [Full text]

Seydoux, G and Braun, R. (2006). Pathway to totipotency: lessons from germ cells. Cell 127, 891-904. [PDF reprint]

Gallo CM, Seydoux G (2006). Toti"potent" repressors. Bioessays. 28(9):865-867 [PDF reprint]

Ingrid D¹Agostino, Chris Merritt, Pei-Lung Chen, Geraldine Seydoux and Kuppuswamy Subramaniam (2006). Translational repression restricts expression of the C. elegans Nanos homolog NOS-2 to the embryonic germline. Developmental Biology 292 244­252. [PDF reprint]

Stitzel, M., Pellettieri, M. and Seydoux, G (2006) The C. elegans DYRK kinase MBK-2 marks oocyte proteins for degradation in response to meiotic maturation. Current Biology 16, 1­7. [PDF reprint] [Supplemental Material]

DeRenzo, C. and Seydoux, G. (2004) A clean start: coordinate degradation of maternal proteins at the egg-to-embryo transition. Trends in Cell Biology 14, 420-428. [PDF reprint]

DeRenzo, C., Reese, K. and Seydoux, G. (2003). Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation. Nature 424, 685-9. [PDF reprint]

Subramaniam, K. and Seydoux, G. (2003). Dedifferentiation of primary spermatocytes into germ cell tumors in C. elegans lacking the Pumilio-like protein PUF-8. Current Biology 13, 134-139. [PDF reprint]

Tenenhaus, C., Subramaniam, K., Dunn, M. Seydoux, G. (2001). PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ lineage of C. elegans. Genes and Development 15, 1031-1040. [PDF reprint]

Reese, K. J., Dunn, M. A., Waddle J. A. and Seydoux, G. (2000). Asymmetric segregation of PIE-1 in C. elegans is mediated by two complementary mechanisms that act through separate PIE-1 protein domains. Molecular Cell 6, 445-455. [PDF reprint]

Seydoux G., and Schedl, T. (2000). The germline in C. elegans: Origins, Proliferation and Silencing. In “Establishment of Cell Lineages and Patterning of the Embryo”, a book in the International Review of Cytology Series edited by Etkin and Jeon.

Subramaniam, K. and Seydoux, G. (1999). nos-1 and nos-2, two genes related to Drosophila nanos, regulate primordial germ cell development and survival in C. elegans. Development 126, 4861-4871. [PDF reprint]

Batchelder, C., Dunn, M. A., Choy, B., Suh, Y., Cassie, C., Shim, E. Y., Shin, T. H., Mello, C., Seydoux, G., Blackwell, T. K. (1999) Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1. Genes and Development 13(2):202-12.

Seydoux, G. and Strome S. (1999). Launching the germline in C. elegans: regulation of gene expression in early germ cells. Development 126, 3275-3283. [PDF reprint]

Tenenhaus, C., Schubert, C., Seydoux, G. (1998). Genetic requirements for PIE-1 localization and inhibition of gene expression in the embryonic germ lineage of Caenorhabditis elegans. Developmental Biology , 200(2):212-24. [PDF reprint]

Seydoux, G. and Dunn, M. (1997). Transcriptionally-repressed germ cells lack a subpopulation of phosphorylated RNA polymerase II in early embryos of C. elegans and D. melanogaster. Development 124, 2191-2201. [PDF reprint]

Seydoux, G., Mello, C. C., Pettitt, J., Wood, W., Priess, J., Fire, A. (1996). Repression of gene expression in the embryonic germ lineage of C. elegans. Nature 382, 713-716.

Other

Seydoux, G (2006) The 2006 GSA medal-Victor Ambros. Genetics, 172(2):721-2. [PDF reprint]

Wallenfang, M. R., and Seydoux, G. (2002). cdk-7 is required for mRNA transcription and cell cycle progression in C. elegans embryos. Proc. Nat. Acad. Sci. 99, 5527-5532. [PDF reprint]

Strome, S. , Powers, J., Dunn, M., Reese, K., Seydoux, G and Saxton, W. (2001). Spindle dynamics and the role of gamma-tubulin in early C. elegans embryos. Mol. Biology of the Cell 12, 1751-64. [PDF reprint]

Golden A., Sadler P. L, Wallenfang, M. R., Schumacher J. M, Hamill, Bates G., Bowerman B., Seydoux, G., and Shakes, D. C. (2000) Metaphase to anaphase transition defective (mat) mutants in Caenorhabditis elegans. Journal of Cell Biology 151, 1469-1482. [PDF reprint]

Prasad, B. C., Ye, B., Zackhary, R., Schrader, K., Seydoux, G., Reed, R. R. (1998). unc-3, a gene required for axonal guidance in Caenorhabditis elegans, encodes a member of the O/E family of transcription factors. Development, 125(8):1561-8

Halpern, M. and Seydoux, G. (2000). Embryo emergent: Elucidating the cell biology of development. Embo Reports 1, 469-472. [PDF reprint]

Seydoux, G. (1996). Mechanisms of translational control in early development. Current Opinion in Genetics and Development 6, 555-561.


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