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The Goley Lab
studying tiny cell biology since 2011
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Species- and C-terminal linker-dependent variations in the dynamic behavior of FtsZ on membranes in vitro.
Sundararajan K, Vecchiarelli AG, Mizuuchi K, Goley ED.
bioRxiv. doi:
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SINCE 2011
Constriction rate modulation can drive cell size control and homeostasis in C. crescentus.
Lambert A, Vanhecke A, Archetti A, Holden S, Schaber F, Pincus Z, Laub MT, Goley E, and Manley S
iScience. In press. (2018)
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FzlA, an essential regulator of FtsZ protofilament curvature, controls constriction rate during Caulobacter division.
Lariviere PJ, Szwedziak P, Mahone CR, Löwe J, and Goley ED
Mol Micro. 107: 180-197. (2018)
Pubmed | Full text

The intrinsically disordered C-terminal linker of FtsZ regulates protofilament dynamics and superstructure
in vitro.
Sundararajan K and Goley ED
J Biol Chem. 292:20509-20527. (2017)
Pubmed | Full text

FtsEX-mediated regulation of the final stages of cell division reveals morphogenetic plasticity in
Caulobacter crescentus.
Meier EL, Yao Q, Daitch AK, Jensen GJ, and Goley ED
PLoS Genetics. 13:e1006999. (2017)
Pubmed | Full text

A conserved coiled-coil protein pair focuses the cytokinetic Z-ring in Caulobacter crescentus.
Woldemeskel SA, McQuillen R, Hessel AM, Xiao J, and Goley ED
Mol Micro. 105:721-740. (2017)
Pubmed | Full text
Selected for cover

Shapeshifting to survive: shape determination and regulation in Caulobacter crescentus.
Woldemeskel SA and Goley ED
Trends Microbiol. 25:673-687. (2017)
Pubmed | Full text

Cytoskeletal proteins in Caulobacter crescentus: spatial orchestrators of cell cycle progression, development, and cell shape.
Sundararajan K and Goley ED
Subcell Biochem. 84:103-137. (2017)
Pubmed | Full text

Redefining the roles of the FtsZ-ring in bacterial cytokinesis.
Xiao J and Goley ED.
Curr Opin Microbiol. 34:90-96. (2016)
Pubmed | Full text

A novel membrane anchor for FtsZ is linked to cell wall hydrolysis in Caulobacter crescentus.
Meier EL, Ravazi S, Inoue T, and Goley ED.
Mol Microbiol. 101:265-280. (2016)
Pubmed | Full text
Selected for

The bacterial tubulin FtsZ requires its intrinsically disordered linker to direct robust cell wall construction.
Sundararajan K, Miguel A, Desmarais SM, Meier EL, Huang KC, and Goley ED.
Nat Commun. 6:7281. (2015)
Pubmed | Full text

Form and function of the bacterial cytokinetic ring.
Meier EL and Goley ED.
Curr Opin Cell Biol. 26:19-27. (2014)
Pubmed | Full text
Selected by
Faculty of 1000

Tiny cells meet big questions: a closer look at bacterial cell biology.
Goley ED
Mol Biol Cell. 24:1099-102. (2013)
Pubmed | Full text

Three-Dimensional Super-Resolution Imaging of the Midplane Protein FtsZ in Live Caulobacter crescentus cells Using Astigmatism.
Biteen JS, Goley ED, Shapiro L, Moerner WE.
Chemphyschem. 12:1007-1012. (2012)
Pubmed | Full text

Assembly of the Caulobacter cell division machine.
Goley ED*, Yeh YC*, Hong SH, Fero MJ, Abeliuk E, McAdams HH, Shapiro L.
Mol. Micro. 80:1680-1698. (2011)
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*These authors contributed equally to this work.

Superresolution Imaging of Targeted Proteins in Living Cells Using Photoactivatable Organic Fluorophores.
Lee HL,
Lord SJ, Iwanaga S, Zhan K, Xie H, Williams JC, Wang H, Bowman GR, Goley ED, Shapiro L, Tweig RJ, Rao J, Moerner WE. 
J Am Chem Soc. 132:15099-15101. (2011)
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Selected by
Faculty of 1000

Imaging-based identification of a critical regulator of FtsZ protofilament curvature in Caulobacter.
Goley ED, Dye NA, Werner JN, Gitai Z, Shapiro L.
Mol. Cell. 39:975-987. (2010)
Pubmed | Full text
Highlighted in: Beuria TK and Margolin W. (2010) Bacterial cytokinesis: FzlA frizzes FtsZ filaments for fission force. Curr. Biol. 20:R1024-R1027. Pubmed
Selected by
Faculty of 1000

DipM links peptidoglycan remodeling to outer membrane organization in Caulobacter.
Goley ED, Comolli LR, Fero KE, Downing KH, Shapiro L.
Mol. Micro. 77:56-73. (2010)
Pubmed | Full text
Highlighted in: Collier J. (2010) A new factor stimulating peptidoglycan hydrolysis to separate daughter cells in Caulobacter crescentus. Mol. Micro. 77:11-14. Pubmed

An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability.
Goley ED, Rammohan A, Znameroski EA, Firat-Karalar EN, Sept D, Welch MD.
Proc. Natl Acad. Sci. U.S.A. 107:8159-64. (2010)
Pubmed | Full text

Dynamic Chromosome Organization and Protein Localization Coordinate the Regulatory Circuitry that Drives the Bacterial Cell Cycle.
Goley ED, Toro E, McAdams HH, Shapiro L.
Cold Spring Harb. Symp. Quant. Biol. 74:55-64.(2009)
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Cell cycle regulation in Caulobacter: location, location, location.
Goley ED, Iniesta AA, Shapiro L.
J. Cell Sci. 120: 3501-7. (2007)
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Dynamic nuclear actin assembly by Arp2/3 complex and a baculovirus WASP-like protein.
Goley ED, Ohkawa T, Mancuso J, Woodruff JB, D’Alessio JA, Cande WZ, Volkman LE, Welch MD.
Science. 314: 464-7. (2006)
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Selected by
Faculty of 1000

The Arp2/3 complex: an actin nucleator comes of age.
Goley ED and MD Welch.
Nat Rev Mol Cell Biol. 7:713-26.(2006)
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NMR analyses of the activation of the Arp2/3 complex by neuronal Wiskott-Aldrich syndrome protein.
Kreishman-Deitrick M, Goley ED, Burdine L, Denison C, Egile C, Li R, Murali N, Kodadek TJ, Welch MD, Rosen MK.
Biochemistry. 44:15247-56. (2005)
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Critical conformational changes in the Arp2/3 complex are induced by nucleotide and nucleation promoting factor.
Goley ED, Rodenbusch SE, Martin AC, Welch MD.
Mol Cell. 16:269-79. (2004)
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A Rickettsia WASP-like protein activates the Arp2/3 complex and mediates actin-based motility.
Jeng RL, Goley ED, D'Alessio JA, Chaga OY, Svitkina TM, Borisy GG, Heinzen RA, Welch MD.
Cell Microbiol. 6: 761-9. (2004)
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Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity.
Gournier H, Goley ED, Niederstrasser H, Trinh T, Welch MD.
Mol Cell. 8:1041-52. (2001)
Pubmed | Full text
Selected by
Faculty of 1000

Pivotal role of VASP in Arp2/3 complex-mediated actin nucleation, actin branch-formation, and
Listeria monocytogenes motility.
Skoble J, Auerbuch V, Goley ED, Welch MD, Portnoy DA.
J Cell Biol. 155:89-100. (2001)
Pubmed | Full text
Selected by
Faculty of 1000